Summary: BRCA1 promotes homologous recombination (HR) by activating DNA-end resection.By contrast, 53BP1 forms a barrier that inhibits DNA-end resection.Here, we show that BRCA1 promotes DNA-end resection by relieving the 53BP1-dependent barrier.We show that 53BP1 is phosphorylated by ATM in S/G2 phase, promoting RIF1 recruitment, which inhibits re
The planar –CH=CHC(=O)– fragment (r.m.s.deviation = 0.074 Å) in the title compound, C18H18O5, connects the planar omnipure q5633 hydroxydimethoxyphenyl (r.m.s.deviation = 0.039 Å) and methoxylphenyl (r.m.s.deviation = 0.021 Å) parts.The central fragment forms a dihedral an
Indentureship had profound and lasting effects on med mizer allcare bed the bodies of those involved.Recruitment processes, along with the harrowing conditions of transport and labour, radically reshaped the material and physical realities of indentured labourers, influencing not only their immediate bodily experiences but also the socio-cultural p